ACS Nano 9, 1408 (2015)
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One
current challenge of magnetic hyperthermia is achieving therapeutic
effects with a minimal amount of nanoparticles, for which improved
heating abilities are continuously pursued. However, it is demonstrated
here that the performance of magnetite nanocubes in a colloidal solution
is reduced by 84% when they are densely packed in three-dimensional
arrangements similar to those found in cell vesicles after nanoparticle
internalization. This result highlights the essential role played by the
nanoparticle arrangement in heating performance, uncontrolled in
applications. A strategy based on the elaboration of nano-objects able
to confine nanocubes in a fixed arrangement is thus considered here to
improve the level of control. The obtained specific absorption rate
results show that nanoworms and nanospheres with fixed one- and
two-dimensional nanocube arrangements, respectively, succeed in reducing
the loss of heating power upon agglomeration, suggesting a change in
the kind of nano-object to be used in magnetic hyperthermia.
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