Showing posts with label Toxicity. Show all posts
Showing posts with label Toxicity. Show all posts

Wednesday, 11 April 2012

Toxicity of SPIONs

Assessing the In Vitro and In Vivo Toxicity of Superparamagnetic Iron Oxide Nanoparticles.
Morteza Mahmoudi, Heinrich Hofmann, Barbara Rothen-Rutishauser,|and Alke Petri-Fink
Chemical Reviews 112, 2323 (2012)
(a) Prominent in vitro assays that are used to probe the impact of nanomaterials on cells; (b) TEM micrograph of a human
liver cell line (HepG2) showing the mechanism of action of representative cell assays (i.e., MTT, checking mitochondria activity; PI, DNA staining; BrdU, DNA replication staining; LDH, membrane integrity assessment).