Fundamentals and advances in magnetic hyperthermia

Fundamentals and advances in magnetic hyperthermia.

E. A. Périgo, G. Hemery, O. Sandre, D. Ortega, E. Garaio, F. Plazaola and F. J. Teran

Appl. Phys. Rev. 2, 041302 (2015)

(a) 3D scatter plot showing the main experimental conditions reported in a set of 120 publications on MH spanning over the last 25 years. Scatter size is proportional to the H0·f product. Green dots of different intensities are the 2D projection of the central scatter over the XY, XZ, and YZ planes. The color code of the spheres is related to the type of assay described in the corresponding publication: red refers to in vivo tests, yellow to in vitro tests, blues to combined in vivo/in vitro tests, and cyan to SAR measurements. The dashed black curve superimposed to the field intensity vs maximum frequency plane indicates the “Brezovich” or H0·f criterion, along which the H0·f = 4.8 × 10⁸ A(ms)⁻¹ condition is fulfilled [note that the experiments complying with this criterion are those below the curve]. (b) Zoom of the most populated region of (a), where the concentration of SAR measurements in the 2005–2009 period an in vivo tests in the 2010–2015 period is shown.